| District ▲ | Winner | Party | Votes | % | Margin |
|---|---|---|---|---|---|
| SC-01 | Tim ScottREP | REP | 233,695 | 65.4% | R+36.7 |
| SC-02 | Joe WilsonREP | REP | 259,672 | 53.5% | R+9.7 |
| SC-03 | Jeff DuncanREP | REP | 202,108 | 62.5% | R+29.6 |
| SC-04 | Trey GowdyREP | REP | 216,838 | 63.5% | R+34.7 |
| SC-05 | REP | 228,286 | 55.1% | R+10.3 | |
| SC-06 | DEM | 199,590 | 62.9% | D+26.4 |