| District ▲ | Winner | Party | Votes | % | Margin |
|---|---|---|---|---|---|
| SC-01 | Mark SanfordREP | REP | 325,170 | 58.6% | R+24.6 |
| SC-02 | Joe WilsonREP | REP | 304,996 | 60.3% | R+25.7 |
| SC-03 | Jeff DuncanREP | REP | 269,540 | 72.8% | R+45.8 |
| SC-04 | Trey GowdyREP | REP | 295,670 | 67.2% | R+36.2 |
| SC-05 | REP | 273,006 | 59.2% | R+20.5 | |
| SC-06 | DEM | 253,901 | 70.1% | D+42.5 | |
| SC-07 | REP | 289,463 | 61.0% | R+25.2 |